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Issue 62, 2012
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DNA detection on lateral flow test strips: enhanced signal sensitivity using LNA-conjugated gold nanoparticles

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Abstract

A lateral flow test strip assay, enabling sensitive detection of DNA specific to the foodborne pathogen E. coli O157:H7, is described. The use of LNA-conjugated gold nanoparticle probes, along with signal amplification protocols, results in minimum detectable concentrations of ∼0.4 nM.

Graphical abstract: DNA detection on lateral flow test strips: enhanced signal sensitivity using LNA-conjugated gold nanoparticles

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Publication details

The article was received on 11 May 2012, accepted on 11 Jun 2012 and first published on 13 Jun 2012


Article type: Communication
DOI: 10.1039/C2CC33430E
Citation: Chem. Commun., 2012,48, 7714-7716
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    DNA detection on lateral flow test strips: enhanced signal sensitivity using LNA-conjugated gold nanoparticles

    S. K. Rastogi, C. M. Gibson, J. R. Branen, D. Eric Aston, A. Larry Branen and P. J. Hrdlicka, Chem. Commun., 2012, 48, 7714
    DOI: 10.1039/C2CC33430E

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