DNA detection on lateral flow test strips: enhanced signal sensitivity using LNA-conjugated gold nanoparticles

Shiva K. Rastogi; CharLene M. Gibson; Josh R. Branen; D. Eric Aston; A. Larry Branen; Patrick J. Hrdlicka

doi:10.1039/C2CC33430E

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Chemical Communications

Issue 62, 2012

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DNA detection on lateral flow test strips: enhanced signal sensitivity using LNA-conjugated gold nanoparticles

Shiva K. Rastogi,*^a^b CharLene M. Gibson,^a Josh R. Branen,^a D. Eric Aston,^c A. Larry Branen^a and Patrick J. Hrdlicka*^b

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Corresponding authors

Biosensors and Nanotechnology Applications Laboratory, University of Idaho, Coeur d’Alene, USA
E-mail: srastogi@uidaho.edu

Department of Chemistry, University of Idaho, Moscow, USA
E-mail: hrdlicka@uidaho.edu

Department of Chemical and Materials Engineering, University of Idaho, Moscow, USA

Chem. Commun., 2012,48, 7714-7716

DOI: 10.1039/C2CC33430E
Received 11 May 2012, Accepted 11 Jun 2012
First published online 13 Jun 2012

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Abstract
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A lateral flow test strip assay, enabling sensitive detection of DNA specific to the foodborne pathogen E. coli O157:H7, is described. The use of LNA-conjugated gold nanoparticle probes, along with signal amplification protocols, results in minimum detectable concentrations of [similar] 0.4 nM.