Issue 69, 2012
From the journal:

Chemical Communications

Ligand effects on the stereochemistry of Stille couplings, as manifested in reactions of Z-alkenyl halides†

Guo-ping Lu,ab   Karl R. Voigtritter,a   Chun Caib  and  Bruce H. Lipshutz*a  

* Corresponding authors

a Department of Chemistry & Biochemistry, University of California, California 93106, Santa Barbara, USA
E-mail: lipshutz@chem.ucsb.edu

b Chemical Engineering College, Nanjing University of Science & Technology, Jiangsu 210094, Nanjing, P. R. China

Abstract

Unexpected losses in stereochemistry from Stille reactions involving Z-alkenyl halides have been shown to be ligand dependent. A new set of reaction conditions has been developed that, in most cases, leads to highly stereoselective cross-couplings under mild conditions, along with improved yields.

Graphical abstract: Ligand effects on the stereochemistry of Stille couplings, as manifested in reactions of Z-alkenyl halides

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Article information

DOI
https://doi.org/10.1039/C2CC33294A
Article type
Communication
Submitted
08 May 2012
Accepted
04 Jul 2012
First published
23 Jul 2012

Chem. Commun., 2012,48, 8661-8663

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Ligand effects on the stereochemistry of Stille couplings, as manifested in reactions of Z-alkenyl halides

G. Lu, K. R. Voigtritter, C. Cai and B. H. Lipshutz, Chem. Commun., 2012, 48, 8661 DOI: 10.1039/C2CC33294A

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