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Issue 61, 2012
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Cascade annulation of malonic diamides: a concise synthesis of polycyclic pyrroloindolines

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Abstract

A concise synthesis of polycyclic pyrroloindolines from simple malonic diamides via an intramolecular oxidative coupling/condensative cyclization cascade process is reported. The reaction provides an efficient method to construct polycyclic pyrroloindolines in good to excellent yields, which should be useful in the synthesis of natural products and pharmaceutical molecules.

Graphical abstract: Cascade annulation of malonic diamides: a concise synthesis of polycyclic pyrroloindolines

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Publication details

The article was received on 01 May 2012, accepted on 07 Jun 2012 and first published on 08 Jun 2012


Article type: Communication
DOI: 10.1039/C2CC33129B
Citation: Chem. Commun., 2012,48, 7571-7573
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    Cascade annulation of malonic diamides: a concise synthesis of polycyclic pyrroloindolines

    F. Fan, W. Xie and D. Ma, Chem. Commun., 2012, 48, 7571
    DOI: 10.1039/C2CC33129B

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