Issue 70, 2012
From the journal:

Chemical Communications

Membrane protein distribution in composite polymer–lipid thin films†

Johannes Thoma,‡a   Serena Belegrinou,‡b   Peggy Rossbach,c   Mariusz Grzelakowski,b   Katarzyna Kita-Tokarczyk§*b  and  Wolfgang Meierb  

* Corresponding authors

a Swiss Nanoscience Institute, University of Basel, Klingelbergstr. 82, 4056 Basel, Switzerland

b Department of Chemistry, University of Basel, Klingelbergstr. 80, 4056 Basel, Switzerland

c Laboratory for Nanoscale Materials Science, Empa - Materials Science and Technology, Überlandstr. 129, 8600 Dübendorf, Switzerland

Abstract

We present a model system to demonstrate that the positioning of biomolecules (membrane proteins) in a nonnative, complex thin film environment can be regulated by the phase behavior of film components. Partial separation between an amphiphilic polymer and a lipid drives the protein to a fluid phase, mechanically more similar to a cellular bilayer.

Graphical abstract: Membrane protein distribution in composite polymer–lipid thin films

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Article information

DOI
https://doi.org/10.1039/C2CC32851H
Article type
Communication
Submitted
21 Apr 2012
Accepted
13 Jul 2012
First published
26 Jul 2012

Chem. Commun., 2012,48, 8811-8813

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Membrane protein distribution in composite polymer–lipid thin films

J. Thoma, S. Belegrinou, P. Rossbach, M. Grzelakowski, K. Kita-Tokarczyk and W. Meier, Chem. Commun., 2012, 48, 8811 DOI: 10.1039/C2CC32851H

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