An enzyme-encapsulated microreactor for efficient theanine synthesis

Shun-ichi Matsuura; Takuji Yokoyama; Ryo Ishii; Tetsuji Itoh; Emiko Tomon; Satoshi Hamakawa; Tatsuo Tsunoda; Fujio Mizukami; Hironobu Nanbu; Taka-aki Hanaoka

doi:10.1039/C2CC32271D

An enzyme-encapsulated microreactor for efficient theanine synthesis†

Shun-ichi Matsuura,*^a Takuji Yokoyama,^b Ryo Ishii,^a Tetsuji Itoh,^a Emiko Tomon,^a Satoshi Hamakawa,^a Tatsuo Tsunoda,^a Fujio Mizukami,^a Hironobu Nanbu^b and Taka-aki Hanaoka^a

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^a Research Center for Compact Chemical System, National Institute of Advanced Industrial Science and Technology (AIST), 4-2-1 Nigatake, Sendai 983-8551, Miyagino-ku, Japan
E-mail: matsuura-shunichi@aist.go.jp
Fax: +81-22-237-5215
Tel: +81-22-237-3039

^b Taiyo Kagaku Co., Ltd., 1-3 Takaramachi, Mie 510-0844, Yokkaichi, Japan

Abstract

A flow-type microreactor containing glutaminase–mesoporous silica composites with 10.6 nm pore diameter (TMPS10.6) was developed for the continuous synthesis of theanine, a unique amino acid. High enzymatic activity was exhibited by the local control of the reaction temperature.

Chemical Communications

An enzyme-encapsulated microreactor for efficient theanine synthesis†

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