Issue 63, 2012

Dynamic asymmetric organocatalysis: cooperative effects of weak interactions and conformational flexibility in asymmetric organocatalysts

Abstract

This review describes recent advances by our research group in the design and applications of conformationally flexible guanidine/bisthiourea organocatalysts to facilitate unique bond-forming processes, including retro-free, enantiodivergent, entropy-controlled, and cycle-specific organocatalysis. Special emphasis is placed on the key requirements to attain high selectivity and on functional switching by exploiting the structural flexibility of our organocatalysts.

Graphical abstract: Dynamic asymmetric organocatalysis: cooperative effects of weak interactions and conformational flexibility in asymmetric organocatalysts

Article information

Article type
Feature Article
Submitted
13 Mar 2012
Accepted
25 May 2012
First published
26 Jun 2012

Chem. Commun., 2012,48, 7777-7789

Dynamic asymmetric organocatalysis: cooperative effects of weak interactions and conformational flexibility in asymmetric organocatalysts

Y. Sohtome and K. Nagasawa, Chem. Commun., 2012, 48, 7777 DOI: 10.1039/C2CC31846F

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