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Issue 42, 2012
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Stereoselective hydrofluorination of ynamides: a straightforward synthesis of novel α-fluoroenamides

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Abstract

α-Fluoroenamides, potent rigid fluorinated bioisosters of ureas, have been synthesized by a highly regio- and stereo-selective hydrofluorination of ynamides in anhydrous HF. This reaction provides the first general entry to α-fluoroenamides and can easily be applied to a wide range of substrates.

Graphical abstract: Stereoselective hydrofluorination of ynamides: a straightforward synthesis of novel α-fluoroenamides

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Publication details

The article was received on 09 Mar 2012, accepted on 23 Mar 2012 and first published on 26 Mar 2012


Article type: Communication
DOI: 10.1039/C2CC31768K
Citation: Chem. Commun., 2012,48, 5196-5198
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    Stereoselective hydrofluorination of ynamides: a straightforward synthesis of novel α-fluoroenamides

    G. Compain, K. Jouvin, A. Martin-Mingot, G. Evano, J. Marrot and S. Thibaudeau, Chem. Commun., 2012, 48, 5196
    DOI: 10.1039/C2CC31768K

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