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Issue 38, 2012
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Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile

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Abstract

The direct aldol reaction of an α-alkyl-α-oxo aldehyde was catalyzed by trifluoromethyl-substituted diarylprolinol 1 to afford a γ-oxo-β-hydroxy-α-substituted aldehyde in good yield with excellent anti-selectivity and excellent enantioselectivity.

Graphical abstract: Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile

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Publication details

The article was received on 18 Feb 2012, accepted on 05 Mar 2012 and first published on 30 Mar 2012


Article type: Communication
DOI: 10.1039/C2CC31230A
Citation: Chem. Commun., 2012,48, 4570-4572
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    Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile

    Y. Hayashi, Y. Yasui, M. Kojima, T. Kawamura and H. Ishikawa, Chem. Commun., 2012, 48, 4570
    DOI: 10.1039/C2CC31230A

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