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Issue 37, 2012
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Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology

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Abstract

We report a highly efficient and selective method for the coupling of peptides and glycoconjugates bearing N-terminal cysteines to activated surfaces. This chemoselective method generates stable amide linkages without using any thiol additives.

Graphical abstract: Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology

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Publication details

The article was received on 06 Feb 2012, accepted on 19 Mar 2012 and first published on 20 Mar 2012


Article type: Communication
DOI: 10.1039/C2CC30844D
Citation: Chem. Commun., 2012,48, 4444-4446
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    Oxo-ester mediated native chemical ligation on microarrays: an efficient and chemoselective coupling methodology

    M. J. Weissenborn, R. Castangia, J. W. Wehner, R. Šardzík, T. K. Lindhorst and S. L. Flitsch, Chem. Commun., 2012, 48, 4444
    DOI: 10.1039/C2CC30844D

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