Issue 41, 2012
From the journal:

Chemical Communications

Isonicotinamide self-association: the link between solvent and polymorph nucleation†

Samir A. Kulkarni,*a   E. S. McGarrity,b   Hugo Meekesc  and  Joop H. ter Horsta  

* Corresponding authors

a Intensified Reaction & Separation Systems, Delft University of Technology, Delft, The Netherlands
E-mail: s.kulkarni@tudelft.nl
Tel: +31 1527 86648

b Engineering Thermodynamics, Delft University of Technology, Delft, The Netherlands

c Radboud University Nijmegen, Institute for Molecules and Materials, Hyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands

Abstract

We show that, in a controlled and reproducible way, specific solvents lead to specific polymorphic forms of isonicotinamide. We argue on the basis of Raman and FTIR spectroscopy that the hydrogen bonding in solution kinetically drives the nucleation towards a specific form. This generally may lead to good understanding and control of polymorphism and crystal nucleation.

Graphical abstract: Isonicotinamide self-association: the link between solvent and polymorph nucleation

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Article information

DOI
https://doi.org/10.1039/C2CC18025A
Article type
Communication
Submitted
22 Dec 2011
Accepted
22 Mar 2012
First published
23 Mar 2012

Chem. Commun., 2012,48, 4983-4985

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Isonicotinamide self-association: the link between solvent and polymorph nucleation

S. A. Kulkarni, E. S. McGarrity, H. Meekes and J. H. ter Horst, Chem. Commun., 2012, 48, 4983 DOI: 10.1039/C2CC18025A

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