Issue 26, 2012
From the journal:

Chemical Communications

Total synthesis of COPD biomarker desmosine that crosslinks elastin†

Toyonobu Usuki,*a   Haruka Yamada,a   Takahiro Hayashi,a   Hiroto Yanuma,a   Yohei Koseki,a   Noriyuki Suzuki,a   Yoshiro Masuyamaa  and  Yong Y. Linb  

* Corresponding authors

a Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Japan
E-mail: t-usuki@sophia.ac.jp
Fax: +81 3 3238 3361
Tel: +81 3 3238 3446

b Department of Medicine, St. Luke’s-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, 432W 58th St, New York, USA
Fax: +1 212 523 7442
Tel: +1 212 523 7305

Abstract

Desmosine, a crosslinking amino acid of elastin, is an attractive biomarker for diagnosis of chronic obstructive pulmonary disease (COPD). In this study, the first total synthesis of (+)-desmosine was achieved in 11% overall yield in 13 steps utilizing stepwise and regioselective Sonogashira cross-coupling reactions.

Graphical abstract: Total synthesis of COPD biomarker desmosine that crosslinks elastin

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2CC17958J
Article type
Communication
Submitted
20 Dec 2011
Accepted
30 Jan 2012
First published
30 Jan 2012

Chem. Commun., 2012,48, 3233-3235

Permissions

Request permissions

Total synthesis of COPD biomarker desmosine that crosslinks elastin

T. Usuki, H. Yamada, T. Hayashi, H. Yanuma, Y. Koseki, N. Suzuki, Y. Masuyama and Y. Y. Lin, Chem. Commun., 2012, 48, 3233 DOI: 10.1039/C2CC17958J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements