Jump to main content
Jump to site search

Issue 14, 2012
Previous Article Next Article

New lithium-zincate approaches for the selective functionalisation of pyrazine: direct dideprotozincation vs. nucleophilic alkylation

Author affiliations

Abstract

Comparing the reactivity of the related lithium zincates [(THF)LiZn(TMP)tBu2] (1) and [(PMDETA)LiZntBu3] (2) towards pyrazine discloses two new bimetallic approaches for the selective 2,5-dideprotonation and room temperature C–H alkylation of this sensitive heterocycle.

Graphical abstract: New lithium-zincate approaches for the selective functionalisation of pyrazine: direct dideprotozincation vs. nucleophilic alkylation

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Nov 2011, accepted on 16 Dec 2011 and first published on 20 Dec 2011


Article type: Communication
DOI: 10.1039/C2CC16959B
Citation: Chem. Commun., 2012,48, 1985-1987
  •   Request permissions

    New lithium-zincate approaches for the selective functionalisation of pyrazine: direct dideprotozincation vs. nucleophilic alkylation

    S. E. Baillie, V. L. Blair, D. C. Blakemore, D. Hay, A. R. Kennedy, D. C. Pryde and E. Hevia, Chem. Commun., 2012, 48, 1985
    DOI: 10.1039/C2CC16959B

Search articles by author

Spotlight

Advertisements