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Issue 1, 2012
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Self-assembling peptide scaffolds for regenerative medicine

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Abstract

Biomaterials made from self-assembling, short peptides and peptide derivatives have great potential to generate powerful new therapies in regenerative medicine. The high signaling capacity and therapeutic efficacy of peptidic scaffolds has been established in several animal models, and the development of more complex, hierarchical structures based on peptide materials is underway. This highlight discusses several classes of self-assembling peptide-based materials, including peptide amphiphiles, Fmoc-peptides, self-complementary ionic peptides, hairpin peptides, and others. The self-assembly designs, bioactive signalling strategies, and cell signalling capabilities of these bioactive materials are reported. The future challenges of the field are also discussed, including short-term goals such as integration with biopolymers and traditional implants, and long term goals, such as immune system programming, subcellular targeting, and the development of highly integrated scaffold systems.

Graphical abstract: Self-assembling peptide scaffolds for regenerative medicine

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Publication details

The article was received on 08 Sep 2011, accepted on 01 Nov 2011 and first published on 14 Nov 2011


Article type: Highlight
DOI: 10.1039/C1CC15551B
Citation: Chem. Commun., 2012,48, 26-33
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    Self-assembling peptide scaffolds for regenerative medicine

    J. B. Matson and S. I. Stupp, Chem. Commun., 2012, 48, 26
    DOI: 10.1039/C1CC15551B

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