Issue 10, 2012

Organocatalytic trifluoromethylation of imines using phase-transfer catalysis with phenoxides. A general platform for catalytic additions of organosilanes to imines

Abstract

A new approach to additions of silicon nucleophiles to imines was developed. The method is based on the phase-transfer of phenoxides by ammonium catalysts, overcoming the inability of amide adducts in promoting the reactions.

Graphical abstract: Organocatalytic trifluoromethylation of imines using phase-transfer catalysis with phenoxides. A general platform for catalytic additions of organosilanes to imines

Supplementary files

Article information

Article type
Communication
Submitted
24 Dec 2010
Accepted
21 Mar 2011
First published
11 Apr 2011

Chem. Commun., 2012,48, 1428-1430

Organocatalytic trifluoromethylation of imines using phase-transfer catalysis with phenoxides. A general platform for catalytic additions of organosilanes to imines

L. Bernardi, E. Indrigo, S. Pollicino and A. Ricci, Chem. Commun., 2012, 48, 1428 DOI: 10.1039/C0CC05777K

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