Issue 21, 2012

Tracing nanoparticlesin vivo: a new general synthesis of positron emitting metal oxidenanoparticles by proton beam activation

Abstract

The synthesis of 18F-labelled positron emitting NPs by direct irradiation of 18O-enriched aluminum oxide NPs with 16 MeV protons is reported. Biodistribution studies of the labelled particles after intravenous administration were performed in male rats using positron emission tomography. The simple and general activation strategy can be applied to any in situ prepared core metal oxide particle for direct use or subsequent bio-compatible coating or encapsulation followed by functionalization.

Graphical abstract: Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation

Supplementary files

Article information

Article type
Communication
Submitted
25 Jun 2012
Accepted
24 Aug 2012
First published
28 Aug 2012

Analyst, 2012,137, 4902-4906

Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation

C. Pérez-Campaña, V. Gómez-Vallejo, A. Martin, E. San Sebastián, S. E. Moya, T. Reese, R. F. Ziolo and J. Llop, Analyst, 2012, 137, 4902 DOI: 10.1039/C2AN35863H

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