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Edge Article

Two design strategies for enhancement of multilayer–DNA-origami folding: underwinding for specific intercalator rescue and staple-break positioning

Yonggang Ke,abc   Gaëtan Bellot,abc   Niels V. Voigt,d   Elena Fradkovabc and   William M. Shih*abc  
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Corresponding authors
a
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, USA
b
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, USA
E-mail: William_Shih@dfci.harvard.edu
c
Wyss Institute for Biologically Inspired Engineering at Harvard, Cambridge, USA
d
Danish National Research Foundation: Centre for DNA Nanotechnology at Interdisciplinary Nanoscience Center (iNANO), and Department of Chemistry, Aarhus University, DK-8000 Aarhus, Denmark
Chem. Sci., 2012,3, 2587-2597

DOI: 10.1039/C2SC20446K
Received 13 Apr 2012, Accepted 18 May 2012
First published online 29 May 2012
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