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Issue 34, 2012
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Palladium-catalyzed, pyrrolidine-mediated arylmethylation of ketones and aldehydes with coumarinyl(methyl) acetates

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Abstract

We report the palladium-catalyzed, pyrrolidine-mediated α-benzylation of enamines generated from aldehydes and ketones. The method allows for direct coupling of medicinally relevant coumarin moieties with aldehydes and ketones in good yield under mild conditions. The reaction is believed to proceed via a Pd–π-benzyl complex generated from (coumarinyl)methyl acetates.

Graphical abstract: Palladium-catalyzed, pyrrolidine-mediated arylmethylation of ketones and aldehydes with coumarinyl(methyl) acetates

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Publication details

The article was received on 18 May 2012, accepted on 06 Jul 2012 and first published on 12 Jul 2012


Article type: Communication
DOI: 10.1039/C2OB25962A
Citation: Org. Biomol. Chem., 2012,10, 6826-6829
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    Palladium-catalyzed, pyrrolidine-mediated arylmethylation of ketones and aldehydes with coumarinyl(methyl) acetates

    K. Cattopadhyay, A. Recio III and J. A. Tunge, Org. Biomol. Chem., 2012, 10, 6826
    DOI: 10.1039/C2OB25962A

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