Issue 50, 2012
From the journal:

Chemical Communications

Enantioselective Friedel–Crafts reactions in water catalyzed by a human telomeric G-quadruplex DNA metalloenzyme†

Changhao Wang,ab   Yinghao Li,ab   Guoqing Jia,a   Yan Liu,a   Shengmei Lua  and  Can Li*a  

* Corresponding authors

a State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China

b Graduate School of Chinese Academy of Sciences, Beijing 100049, China
E-mail: canli@dicp.ac.cn

Abstract

A human telomeric G-quadruplex (G4DNA) metalloenzyme, assembled with G4DNA and Cu2+ ions, can catalyze the enantioselective Friedel–Crafts (F–C) reaction in water with good enantioselectivity (up to 75% ee). Furthermore, we found that the absolute configuration and the enantioselectivity of the product largely depend on the conformation and the sequence of G4DNA.

Graphical abstract: Enantioselective Friedel–Crafts reactions in water catalyzed by a human telomeric G-quadruplex DNA metalloenzyme

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Article information

DOI
https://doi.org/10.1039/C2CC31320K
Article type
Communication
Submitted
22 Feb 2012
Accepted
02 May 2012
First published
03 May 2012

Chem. Commun., 2012,48, 6232-6234

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Enantioselective Friedel–Crafts reactions in water catalyzed by a human telomeric G-quadruplex DNA metalloenzyme

C. Wang, Y. Li, G. Jia, Y. Liu, S. Lu and C. Li, Chem. Commun., 2012, 48, 6232 DOI: 10.1039/C2CC31320K

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