Issue 37, 2012

Corrin ring-induced redox tuning

Abstract

The density functional calculations suggest that the expansion of the corrin macrocycle's N4 core by 0.06–0.10 Å leads to an appreciable lowering of 100–150 mV vs. saturated calomel electrode in the reduction potentials of two biologically important B12 cofactors namely methylcobalamin and adenosylcobalamin respectively. This redox tuning of B12 cofactors may encourage the electron transfer-based activation mechanism for B12-dependent enzymes.

Graphical abstract: Corrin ring-induced redox tuning

Supplementary files

Article information

Article type
Communication
Submitted
23 Jan 2012
Accepted
06 Feb 2012
First published
08 Mar 2012

Chem. Commun., 2012,48, 4456-4458

Corrin ring-induced redox tuning

M. Kumar and P. M. Kozlowski, Chem. Commun., 2012, 48, 4456 DOI: 10.1039/C2CC30529A

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