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Issue 14, 2013
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[18F]Fluorination of an arylboronic ester using [18F]selectfluor bis(triflate): application to 6-[18F]fluoro-L-DOPA

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Abstract

The Ag-mediated electrophilic [18F]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [18F]selectfluor bis(triflate) in acetone. The process gave 6-[18F]fluoro-L-DOPA with a RCY of 19 ± 12% and a specific activity of 2.6 ± 0.3 GBq μmol−1.

Graphical abstract: [18F]Fluorination of an arylboronic ester using [18F]selectfluor bis(triflate): application to 6-[18F]fluoro-l-DOPA

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Publication details

The article was received on 02 Dec 2012, accepted on 02 Jan 2013 and first published on 03 Jan 2013


Article type: Communication
DOI: 10.1039/C2CC38646A
Citation: Chem. Commun., 2013,49, 1386-1388
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    [18F]Fluorination of an arylboronic ester using [18F]selectfluor bis(triflate): application to 6-[18F]fluoro-L-DOPA

    I. S. R. Stenhagen, A. K. Kirjavainen, S. J. Forsback, C. G. Jørgensen, E. G. Robins, S. K. Luthra, O. Solin and V. Gouverneur, Chem. Commun., 2013, 49, 1386
    DOI: 10.1039/C2CC38646A

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