Issue 12, 2013
From the journal:

Chemical Communications

Tris-(2-carboxyethyl) phosphine significantly promotes the reaction of cisplatin with Sp1 zinc finger protein†

Siming Chen,a   Huan Jiang,a   Kaiju Weia  and  Yangzhong Liu*a  

* Corresponding authors

a CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui, China
E-mail: liuyz@ustc.edu.cn
Tel: +86-551-3600874

Abstract

A widely used reducing agent tris-(2-carboxyethyl) phosphine significantly promotes the reaction of cisplatin with Sp1 zinc finger protein. This discovery clarifies the reactivity of cisplatin towards Sp1 zinc finger protein and implies that the reactions of platinum drugs could be largely influenced by small molecules with a strong trans effect.

Graphical abstract: Tris-(2-carboxyethyl) phosphine significantly promotes the reaction of cisplatin with Sp1 zinc finger protein

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Article information

DOI
https://doi.org/10.1039/C2CC38517A
Article type
Communication
Submitted
27 Nov 2012
Accepted
19 Dec 2012
First published
19 Dec 2012

Chem. Commun., 2013,49, 1226-1228

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Tris-(2-carboxyethyl) phosphine significantly promotes the reaction of cisplatin with Sp1 zinc finger protein

S. Chen, H. Jiang, K. Wei and Y. Liu, Chem. Commun., 2013, 49, 1226 DOI: 10.1039/C2CC38517A

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