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Issue 5, 2013
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Painting proteins blue: β-(1-azulenyl)-L-alanine as a probe for studying proteinprotein interactions

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Abstract

We demonstrated that β-(1-azulenyl)-L-alanine, a fluorescent pseudoisosteric analog of tryptophan, exhibits weak environmental dependence and thus allows for using weak intrinsic quenchers, such as methionines, to monitor proteinprotein interactions while not perturbing them.

Graphical abstract: Painting proteins blue: β-(1-azulenyl)-l-alanine as a probe for studying protein–protein interactions

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Publication details

The article was received on 16 Oct 2012, accepted on 20 Nov 2012 and first published on 21 Nov 2012


Article type: Communication
DOI: 10.1039/C2CC37550H
Citation: Chem. Commun., 2013,49, 490-492
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    Painting proteins blue: β-(1-azulenyl)-L-alanine as a probe for studying proteinprotein interactions

    Y. S. Moroz, W. Binder, P. Nygren, G. A. Caputo and I. V. Korendovych, Chem. Commun., 2013, 49, 490
    DOI: 10.1039/C2CC37550H

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