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Issue 57, 2012
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Synthetic mammalian riboswitches based on guanine aptazyme

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Abstract

Allosteric hammerhead ribozymes (aptazymes) that are activated by guanine were used to control mammalian gene expression in cis and in trans. Coexpression of the two mechanistically distinct riboswitches resulted in an improved dynamic range of gene expression.

Graphical abstract: Synthetic mammalian riboswitches based on guanine aptazyme

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Publication details

The article was received on 02 May 2012, accepted on 29 May 2012 and first published on 30 May 2012


Article type: Communication
DOI: 10.1039/C2CC33140C
Citation: Chem. Commun., 2012,48, 7215-7217
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    Synthetic mammalian riboswitches based on guanine aptazyme

    Y. Nomura, D. Kumar and Y. Yokobayashi, Chem. Commun., 2012, 48, 7215
    DOI: 10.1039/C2CC33140C

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