Jump to main content
Jump to site search

Issue 45, 2012
Previous Article Next Article

An efficient synthetic approach to 6,5′-(S)- and 6,5′-(R)-cyclouridine

Author affiliations

Abstract

Here we present new routes for the efficient syntheses of 6,5′-(S)- and 6,5′-(R)-cyclouridine. The syntheses utilize readily accessible uridine as a starting material. This route to the R diastereomer is significantly more efficient than previous synthetic efforts, allowing us to obtain large amounts of pure material for future biological testing.

Graphical abstract: An efficient synthetic approach to 6,5′-(S)- and 6,5′-(R)-cyclouridine

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Mar 2012, accepted on 03 Apr 2012 and first published on 10 Apr 2012


Article type: Communication
DOI: 10.1039/C2CC31597A
Citation: Chem. Commun., 2012,48, 5587-5589
  •   Request permissions

    An efficient synthetic approach to 6,5′-(S)- and 6,5′-(R)-cyclouridine

    C. S. Theile and L. W. McLaughlin, Chem. Commun., 2012, 48, 5587
    DOI: 10.1039/C2CC31597A

Search articles by author

Spotlight

Advertisements