Issue 1, 2013
From the journal:

Analytical Methods

Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: self-reporting scaffolds for application in tissue engineering†

H. C. Harrington,a   F. R. A. J. Rose,b   Y. Reinwald,b   L. D. K. Buttery,b   A. M. Ghaemmaghamic  and  J. W. Aylott*a  

* Corresponding authors

a Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, UK
E-mail: jon.aylott@nottingham.ac.uk

b Division of Drug Delivery and Tissue Engineering, Centre for Biomolecular Sciences, University of Nottingham, UK

c Allergy Research Group, School of Molecular Medical Sciences, University of Nottingham, UK

Abstract

Ratiometric analyte responsive nanosensors have been incorporated into electrospun poly(lactic-co-glycolic) acid (PLGA) fibres to create self-reporting scaffolds. It has been demonstrated that the self-reporting scaffolds could be utilised to monitor microenvironment conditions without damaging the fabricated scaffold or the cells being cultured upon the construct. This presents opportunities to fully understand, monitor and optimise the growth of 3D model tissue constructs in vitro.

Graphical abstract: Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: self-reporting scaffolds for application in tissue engineering

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Article information

DOI
https://doi.org/10.1039/C2AY25771H
Article type
Communication
Submitted
18 Jul 2012
Accepted
13 Nov 2012
First published
27 Nov 2012

Anal. Methods, 2013,5, 68-71

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Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: self-reporting scaffolds for application in tissue engineering

H. C. Harrington, F. R. A. J. Rose, Y. Reinwald, L. D. K. Buttery, A. M. Ghaemmaghami and J. W. Aylott, Anal. Methods, 2013, 5, 68 DOI: 10.1039/C2AY25771H

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