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Issue 23, 2011
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Self-assembly and drug delivery studies of pH/thermo-sensitive polyampholytic (A-co-B)-b-C-b-(A-co-B) segmented terpolymers

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Abstract

We investigated the behavior of the pH and thermo-responsive poly(2-(diethylamino)ethyl methacrylate-co-methacrylic acid)-b-(ethylene glycol methyl ether methacrylate)-b-poly(2-(diethylamino)ethyl methacrylate-co-methacrylic acid) (P(DEAEMA-co-MAA)-b-PEGMA-b-P(DEAEMA-co-MAA)) triblock terpolymers in aqueous solution by means of static and dynamic light scattering, transmission electron microscopy and rheology. Association phenomena were observed at the isoelectric point region of the polyampholyte outer blocks leading to flower-like micelles and at higher polymer concentrations, to a three dimensional transient micellar network, exhibiting a compex thermo-response thanks to the thermo-sensitivity of the PEGMA middle block. Doxorubicin (DOX) drug was loaded in the terpolymer micelles and drug release studies were performed. Controlled drug delivery could be achieved by tuning pH. The terpolymer micelles exhibited satisfactory cytocompatibility towards human umbilical vein endothelial cells.

Graphical abstract: Self-assembly and drug delivery studies of pH/thermo-sensitive polyampholytic (A-co-B)-b-C-b-(A-co-B) segmented terpolymers

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Publication details

The article was received on 24 Jun 2011, accepted on 01 Sep 2011 and first published on 13 Oct 2011


Article type: Paper
DOI: 10.1039/C1SM06185B
Citation: Soft Matter, 2011,7, 11160-11168
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    Self-assembly and drug delivery studies of pH/thermo-sensitive polyampholytic (A-co-B)-b-C-b-(A-co-B) segmented terpolymers

    Z. Iatridi, G. Mattheolabakis, K. Avgoustakis and C. Tsitsilianis, Soft Matter, 2011, 7, 11160
    DOI: 10.1039/C1SM06185B

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