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Issue 14, 2011
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Physicochemical, biological and drug-release properties of gallium crosslinked alginate/nanoparticulate bioactive glass composite films

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Abstract

The aim of this work was to develop biodegradable and bioactive materials with sufficient structural integrity and prophylaxis effect against infection based on alginate-bioactive glass composite. The incorporation of bioactive glass nanoparticles (NBG) into Ga-crosslinked alginate films significantly improved their mechanical properties when compared with films fabricated with micron-sized bioactive glass particles. In addition, Ga-alginate films containing NBG induced a bacteriostatic effect in vitro towards S. aureus due to the presence of Ga ions (Ga3+), whose release is controlled solely by crosslinking the ion with alginate. Biomineralization studies in simulated body fluid suggested the deposition of hydroxyapatite on the surface of the films indicating their bioactive nature. In addition, the films were shown to feature biocompatibility toward osteoblast-like cells. Thus, it was shown that Ga-crosslinked composite films possessed relevant physicochemical, biological and controlled bacteriostatic effects which make these materials promising candidates for bone tissue engineering applications.

Graphical abstract: Physicochemical, biological and drug-release properties of gallium crosslinked alginate/nanoparticulate bioactive glass composite films

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Publication details

The article was received on 24 Feb 2011, accepted on 08 Apr 2011 and first published on 20 Jun 2011


Article type: Paper
DOI: 10.1039/C1SM05331K
Citation: Soft Matter, 2011,7, 6705-6712
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    Physicochemical, biological and drug-release properties of gallium crosslinked alginate/nanoparticulate bioactive glass composite films

    V. Mouriño, P. Newby, F. Pishbin, J. P. Cattalini, S. Lucangioli and A. R. Boccaccini, Soft Matter, 2011, 7, 6705
    DOI: 10.1039/C1SM05331K

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