Jump to main content
Jump to site search

Issue 6, 2011
Previous Article Next Article

Shell-sheddable micelles based on star-shaped poly(ε-caprolactone)-SS-poly(ethyl glycol) copolymer for intracellular drug release

Author affiliations

Abstract

We report on the preparation and drug delivery application of shell sheddable micelles based on disulfide-linked star-shaped copolymer of poly(ε-caprolactone) and poly(ethyl glycol) (6sPCL-SS-PEG). Interestingly, the micelles exhibit high stability normally and rapid destabilization under a reduction environment, eliciting GSH dependent cytotoxicity of drug-loaded formulations on tumor cells.

Graphical abstract: Shell-sheddable micelles based on star-shaped poly(ε-caprolactone)-SS-poly(ethyl glycol) copolymer for intracellular drug release

Back to tab navigation

Supplementary files

Additions and corrections

Publication details

The article was received on 07 Jan 2011, accepted on 24 Jan 2011 and first published on 15 Feb 2011


Article type: Communication
DOI: 10.1039/C1SM05020F
Citation: Soft Matter, 2011,7, 2329-2331
  •   Request permissions

    Shell-sheddable micelles based on star-shaped poly(ε-caprolactone)-SS-poly(ethyl glycol) copolymer for intracellular drug release

    T. Ren, Y. Feng, Z. Zhang, L. Li and Y. Li, Soft Matter, 2011, 7, 2329
    DOI: 10.1039/C1SM05020F

Search articles by author

Spotlight

Advertisements