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Issue 12, 2011
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The first example of the direct asymmetric conjugate addition of aldehydes to a methylenemalonate promoted by an axially chiral amino diol catalyst

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Abstract

A methylenemalonate could be employed as a reactive equivalent of a three carbon Michael acceptor such as acrylate in a direct asymmetric conjugate addition of aldehydes catalyzed by an axially chiral amino diol. The obtained conjugate addition product was readily converted to synthetically useful and important chiral building blocks.

Graphical abstract: The first example of the direct asymmetric conjugate addition of aldehydes to a methylenemalonate promoted by an axially chiral amino diol catalyst

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Publication details

The article was received on 12 Jul 2011, accepted on 07 Aug 2011 and first published on 26 Aug 2011


Article type: Edge Article
DOI: 10.1039/C1SC00453K
Citation: Chem. Sci., 2011,2, 2311-2313
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    The first example of the direct asymmetric conjugate addition of aldehydes to a methylenemalonate promoted by an axially chiral amino diol catalyst

    T. Kano, F. Shirozu, K. Tatsumi, Y. Kubota and K. Maruoka, Chem. Sci., 2011, 2, 2311
    DOI: 10.1039/C1SC00453K

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