Jump to main content
Jump to site search

Issue 1, 2012
Previous Article Next Article

Synthesis of star and H-shape polymersvia a combination of cobalt-mediated radical polymerization and nitrone-mediated radical coupling reactions

Author affiliations

Abstract

Via consecutive cobalt-mediated radical polymerization (CMRP), nitrone-mediated radical coupling (NMRC) and copper catalyzed azide-alkyne cycloaddition (CuAAC), polymers with mikto-arm star and H-shape architecture were synthesized. Poly(vinyl acetate)40-block-poly(acrylonitrile)78-Co(acac)2polymers were synthesized viaCMRC and subsequently coupled using an alkyne functional nitrone. The coupling efficiency of the NMRC process was assessed employing N-tert-butyl α-phenyl nitrone (PBN), which is structurally very similar to the later employed coupling agent. Generally, coupling efficiencies of close to 90% or higher were observed in all cases. Since the coupling reaction yields triblock copolymers bearing an alkoxyamine functionality (and thus also an alkyne group) in the middle of the chain, well defined PEG conjugates could be obtained viaCuAAC. Miktoarm star polymers of the structure (PVAc-b-PAN)2-PEG were generated as well as H-shaped material of the structure (PVAc-b-PAN)2-PEG-(PVAc-b-PAN)2via conjugation with bifunctional PEG. In all cases, very narrow molecular weight material was obtained. Molecular weight analysis of the intermediate and the final products reveals that the hydrodynamic volume of the miktoarm star and the H-shaped materials is not substantially increased during the final conjugation reaction despite the fact that the absolute molecular weight increases by more than a factor of two in the latter case. Success of the conjugation reactions was confirmed via composition analysis viaNMR.

Graphical abstract: Synthesis of star and H-shape polymersvia a combination of cobalt-mediated radical polymerization and nitrone-mediated radical coupling reactions

Back to tab navigation

Supplementary files

Publication details

The article was received on 30 Jun 2011, accepted on 25 Jul 2011 and first published on 12 Sep 2011


Article type: Paper
DOI: 10.1039/C1PY00297J
Citation: Polym. Chem., 2012,3, 135-147
  •   Request permissions

    Synthesis of star and H-shape polymersvia a combination of cobalt-mediated radical polymerization and nitrone-mediated radical coupling reactions

    C. Detrembleur, A. Debuigne, O. Altintas, M. Conradi, E. H. H. Wong, C. Jérôme, C. Barner-Kowollik and T. Junkers, Polym. Chem., 2012, 3, 135
    DOI: 10.1039/C1PY00297J

Search articles by author

Spotlight

Advertisements