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Issue 10, 2011
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Stealth macromolecular platforms for the design of MRI blood pool contrast agents

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Abstract

Stealth macromolecular platforms bearing alkyne groups and poly(ethylene oxide) brushes were synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization. The anchoring of Gd3+-chelates bearing an azide group was then carried out by the Huisgen 1,3-dipolar cycloaddition (“click”) reaction in mild conditions, leading to macrocontrast agents for MRI applications. The gadolinium complex is hidden in the PEO shell that renders the macrocontrast agents free of any cytotoxicity and stealth to proteins of the immune system. Relaxometry measurements have evidenced an improved relaxivity of the macrocontrast agent compared to ungrafted gadolinium chelate. Moreover, this relaxivity is further enhanced when the spacer length between the Gd3+-chelate and the polymer backbone is shorter, as the result of its decreased tumbling rate. These novel products are therefore promising candidates for MRI applications.

Graphical abstract: Stealth macromolecular platforms for the design of MRI blood pool contrast agents

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Publication details

The article was received on 05 May 2011, accepted on 09 Jun 2011 and first published on 28 Jul 2011


Article type: Paper
DOI: 10.1039/C1PY00198A
Citation: Polym. Chem., 2011,2, 2316-2327
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    Stealth macromolecular platforms for the design of MRI blood pool contrast agents

    M. Grogna, R. Cloots, A. Luxen, C. Jérôme, C. Passirani, N. Lautram, Jean-F. Desreux, M. Collodoro, M. De Pauw-Gillet and C. Detrembleur, Polym. Chem., 2011, 2, 2316
    DOI: 10.1039/C1PY00198A

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