Issue 10, 2012

Concise synthesis of an enantiopure bicyclic pyrazinone as constrained peptidomimetic building block

Abstract

A concise synthetic route has been developed for the preparation of a constrained peptidomimetic pyrazinone building block. From hydroxy-L-lysine, the desired pyrazinone is obtained in 43% overall yield (6 steps) via an efficient deprotection–double cyclization sequence.

Graphical abstract: Concise synthesis of an enantiopure bicyclic pyrazinone as constrained peptidomimetic building block

Supplementary files

Article information

Article type
Paper
Submitted
20 Oct 2011
Accepted
05 Jan 2012
First published
06 Jan 2012

Org. Biomol. Chem., 2012,10, 2003-2007

Concise synthesis of an enantiopure bicyclic pyrazinone as constrained peptidomimetic building block

V. Gembus, S. Janvier, J. Lecouvé, L. Vaysse-Ludot, J. Brière and V. Levacher, Org. Biomol. Chem., 2012, 10, 2003 DOI: 10.1039/C2OB06762E

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