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Issue 21, 2011
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pH-Responsive self-duplex of PyA-substituted oligodeoxyadenylate in graphene oxide solution as a molecular switch

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Abstract

In this paper, we demonstrated a highly discriminated and reliable molecular switch based on the interaction between the self-duplex of PyA-substituted oligodeoxyadenylate and graphene oxide in aqueous solution. This system showed a clear on/off state through the association and dissociation of PyA-modified oligodeoxynucleotide with graphene oxide in manipulated pH conditions, high amplitude efficiency for at least 50 cycles, and rapid response within seconds. Our molecular switch system has high reproducibility and simple operation by using pH stimulus.

Graphical abstract: pH-Responsive self-duplex of PyA-substituted oligodeoxyadenylate in graphene oxide solution as a molecular switch

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Publication details

The article was received on 28 Jun 2011, accepted on 04 Aug 2011 and first published on 05 Aug 2011


Article type: Paper
DOI: 10.1039/C1OB06037F
Citation: Org. Biomol. Chem., 2011,9, 7434-7438
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    pH-Responsive self-duplex of PyA-substituted oligodeoxyadenylate in graphene oxide solution as a molecular switch

    J. W. Yi, J. Park, K. S. Kim and B. H. Kim, Org. Biomol. Chem., 2011, 9, 7434
    DOI: 10.1039/C1OB06037F

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