Issue 15, 2011
From the journal:

Organic & Biomolecular Chemistry

N-Fmoc-α-sulfo-β-alanine: a versatile building block for the water solubilisation of chromophores and fluorophores by solid-phase strategy†

Anthony Romieu,*ab   Thomas Bruckdorfer,d   Guillaume Clavé,a   Virgile Grandclaude,a   Cédrik Massifa  and  Pierre-Yves Renardabc  

* Corresponding authors

a Equipe de Chimie Bio-Organique, COBRA-CNRS UMR 6014 & FR 3038, rue Lucien Tesnière, 76131 Mont-Saint-Aignan, France
E-mail: anthony.romieu@univ-rouen.fr
Web: http://ircof.crihan.fr
Fax: +33 2-35-52-29-71
Tel: +33 2-35-52-24-27

b Université de Rouen, Place Emile Blondel, 76821 Mont-Saint-Aignan, France

c Institut Universitaire de France, 103 Boulevard Saint-Michel, Paris, France

d Iris Biotech GmbH, Waldershofer Str. 49-51, 95615 Marktredwitz, Germany
Web: www.iris-biotech.de

Abstract

An easy and efficient solid-phase synthesis strategy to obtain rapidly water-soluble chromophores/fluorophores in highly pure form has been developed. This first successful use of N-Fmoc-α-sulfo-β-alanine as a SPPS building block opens the way to the future development of promising direct “on-resin” peptide labelling and water-solubilising methods.

Graphical abstract: N-Fmoc-α-sulfo-β-alanine: a versatile building block for the water solubilisation of chromophores and fluorophores by solid-phase strategy

About
Cited by
Related
Download options Please wait...

Supplementary files

Additions and corrections

Article information

DOI
https://doi.org/10.1039/C1OB05730H
Article type
Communication
Submitted
09 May 2011
Accepted
27 May 2011
First published
27 May 2011

Org. Biomol. Chem., 2011,9, 5337-5342

Permissions

Request permissions

N-Fmoc-α-sulfo-β-alanine: a versatile building block for the water solubilisation of chromophores and fluorophores by solid-phase strategy

A. Romieu, T. Bruckdorfer, G. Clavé, V. Grandclaude, C. Massif and P. Renard, Org. Biomol. Chem., 2011, 9, 5337 DOI: 10.1039/C1OB05730H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements