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Issue 18, 2011
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Copper-catalyzed reductive coupling of tosylhydrazones with amines: A convenient route to α-branched amines

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Abstract

A general procedure for the reductive coupling of N-tosylhydrazones with amines in the presence of Cu(acac)2 and Cs2CO3 has been developed. The protocol is very effective and chemoselective with various primary and secondary aliphatic amines, aminoalcohols as well as azole derivatives to give α-branched amines in good yields.

Graphical abstract: Copper-catalyzed reductive coupling of tosylhydrazones with amines: A convenient route to α-branched amines

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Publication details

The article was received on 28 Apr 2011, accepted on 06 Jul 2011 and first published on 12 Jul 2011


Article type: Communication
DOI: 10.1039/C1OB05664F
Citation: Org. Biomol. Chem., 2011,9, 6200-6204
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    Copper-catalyzed reductive coupling of tosylhydrazones with amines: A convenient route to α-branched amines

    A. Hamze, B. Tréguier, J. Brion and M. Alami, Org. Biomol. Chem., 2011, 9, 6200
    DOI: 10.1039/C1OB05664F

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