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Issue 14, 2011
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Pyrrolidinyl-sulfamide derivatives as a new class of bifunctional organocatalysts for direct asymmetric Michael addition of cyclohexanone to nitroalkenes

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Abstract

A series of chiral pyrrolidinyl-sulfamide derivatives have been identified as efficient bifunctional organocatalysts for the direct Michael addition of cyclohexanone to a wide range of nitroalkenes. The desired Michael adducts were obtained in high chemical yields and excellent stereoselectivities (up to 99/1 dr and 95% ee).

Graphical abstract: Pyrrolidinyl-sulfamide derivatives as a new class of bifunctional organocatalysts for direct asymmetric Michael addition of cyclohexanone to nitroalkenes

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Publication details

The article was received on 21 Mar 2011, accepted on 28 Apr 2011 and first published on 28 Apr 2011


Article type: Paper
DOI: 10.1039/C1OB05442B
Citation: Org. Biomol. Chem., 2011,9, 5280-5287
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    Pyrrolidinyl-sulfamide derivatives as a new class of bifunctional organocatalysts for direct asymmetric Michael addition of cyclohexanone to nitroalkenes

    J. Chen, L. Fu, Y. Zou, N. Chang, J. Rong and W. Xiao, Org. Biomol. Chem., 2011, 9, 5280
    DOI: 10.1039/C1OB05442B

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