Issue 14, 2011

Pyrrolidinyl-sulfamide derivatives as a new class of bifunctional organocatalysts for direct asymmetric Michael addition of cyclohexanone to nitroalkenes

Abstract

A series of chiral pyrrolidinyl-sulfamide derivatives have been identified as efficient bifunctional organocatalysts for the direct Michael addition of cyclohexanone to a wide range of nitroalkenes. The desired Michael adducts were obtained in high chemical yields and excellent stereoselectivities (up to 99/1 dr and 95% ee).

Graphical abstract: Pyrrolidinyl-sulfamide derivatives as a new class of bifunctional organocatalysts for direct asymmetric Michael addition of cyclohexanone to nitroalkenes

Supplementary files

Article information

Article type
Paper
Submitted
21 Mar 2011
Accepted
28 Apr 2011
First published
28 Apr 2011

Org. Biomol. Chem., 2011,9, 5280-5287

Pyrrolidinyl-sulfamide derivatives as a new class of bifunctional organocatalysts for direct asymmetric Michael addition of cyclohexanone to nitroalkenes

J. Chen, L. Fu, Y. Zou, N. Chang, J. Rong and W. Xiao, Org. Biomol. Chem., 2011, 9, 5280 DOI: 10.1039/C1OB05442B

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