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Issue 16, 2011
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Artificial polymeric receptors on the cell surface promote the efficient cellular uptake of quantum dots

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Abstract

In our previous paper, secondary-amine appended cationic polymer 1 was used as a scaffold to display artificial receptors on a cell surface (R. Kamitani et al., ChemBioChem, 2009, 10, 230). This polymer can be retained on the cell surface for more than 30 min before being slowly internalized into the cells. In this study, our aim is to achieve the efficient internalization of quantum dots (QDs) into target cellsvia artificial receptors on the polymer. As a receptor molecule, N-acetylglucosamine (GlcNAc) moieties were introduced into the polymer, and GlcNAc binding protein-displaying QDs were used as a ligand. We found that ligand-presenting QDs could be internalized effectively into cellsviapolymer-mediated endocytosis, whereas QDs were not internalized into untreated cells. These data suggest that our method based on cell-surface engineering using polymers affords a new approach to the delivery of various poorly permeable nanoparticles into cells.

Graphical abstract: Artificial polymeric receptors on the cell surface promote the efficient cellular uptake of quantum dots

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Publication details

The article was received on 17 Mar 2011, accepted on 18 May 2011 and first published on 07 Jul 2011


Article type: Paper
DOI: 10.1039/C1OB05420A
Citation: Org. Biomol. Chem., 2011,9, 5787-5792
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    Artificial polymeric receptors on the cell surface promote the efficient cellular uptake of quantum dots

    K. Niikura, K. Nambara, T. Okajima, R. Kamitani, S. Aoki, Y. Matsuo and K. Ijiro, Org. Biomol. Chem., 2011, 9, 5787
    DOI: 10.1039/C1OB05420A

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