Issue 9, 2011
From the journal:

Organic & Biomolecular Chemistry

Structure elucidation and biosynthesis of lysine-rich cyclic peptides in Xenorhabdus nematophila†

Sebastian W. Fuchs,a   Anna Proschak,a   Thorsten W. Jaskolla,b   Michael Karasb  and  Helge B. Bode*a  

* Corresponding authors

a Molekulare Biotechnologie, Institut für Molekulare Biowissenschaften, Goethe Universität Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany
E-mail: h.bode@bio.uni-frankfurt.de
Fax: +49 69 798 29527
Tel: +49 69 798 29557

b Cluster of Excellence Macromolecular Complexes, Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, 60438 Frankfurt, Germany

Abstract

Thirteen novel PAX (peptide-antimicrobial-Xenorhabdus) peptides were identified in Xenorhabdus nematophilaHGB081. Their structures including the absolute configuration were elucidated using a combination of labeling experiments, detailed MS/MS experiments, the advanced Marfey's method, and a detailed analysis of the biosynthesis gene cluster, which was identified as well.

Graphical abstract: Structure elucidation and biosynthesis of lysine-rich cyclic peptides in Xenorhabdus nematophila

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1OB05097D
Article type
Communication
Submitted
18 Jan 2011
Accepted
09 Feb 2011
First published
10 Feb 2011

Org. Biomol. Chem., 2011,9, 3130-3132

Permissions

Request permissions

Structure elucidation and biosynthesis of lysine-rich cyclic peptides in Xenorhabdus nematophila

S. W. Fuchs, A. Proschak, T. W. Jaskolla, M. Karas and H. B. Bode, Org. Biomol. Chem., 2011, 9, 3130 DOI: 10.1039/C1OB05097D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements