Issue 10, 2011
From the journal:

Organic & Biomolecular Chemistry

A novel acid-catalyzed C5-alkylation of oxindoles using alcohols†

Chada Raji Reddy,*a   Enukonda Jithender,a   Gaddam Krishna,a   Gunreddy Venkat Reddyb  and  Bharatam Jagadeeshb  

* Corresponding authors

a Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 607, India
E-mail: rajireddy@iict.res.in
Fax: +91-40-27160512

b Center for NMR, Indian Institute of Chemical Technology, Hyderabad 500 607, India

Abstract

A novel C5-alkylation of oxindoles using alcohols as alkylating agents under acid catalysis is described for the first time. The reactions of various benzylic, allylic and propargylic alcohols are studied to obtain the corresponding 5-substituted oxindoles in good yields.

Graphical abstract: A novel acid-catalyzed C5-alkylation of oxindoles using alcohols

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Article information

DOI
https://doi.org/10.1039/C0OB01144D
Article type
Paper
Submitted
09 Dec 2010
Accepted
07 Mar 2011
First published
07 Mar 2011

Org. Biomol. Chem., 2011,9, 3940-3947

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A novel acid-catalyzed C5-alkylation of oxindoles using alcohols

C. R. Reddy, E. Jithender, G. Krishna, G. V. Reddy and B. Jagadeesh, Org. Biomol. Chem., 2011, 9, 3940 DOI: 10.1039/C0OB01144D

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