Issue 4, 2011

Asymmetric organocatalytic Michael–α-amination sequence for the construction of a quaternary stereocenter

Abstract

Combination of secondary and primary amine-catalyzed organocascade Michael–α-amination is described. This sequence afforded α-hydrazino aldehydes bearing a quaternary stereocenter with high yield and excellent stereoselectivity.

Graphical abstract: Asymmetric organocatalytic Michael–α-amination sequence for the construction of a quaternary stereocenter

Supplementary files

Article information

Article type
Communication
Submitted
20 Sep 2010
Accepted
18 Nov 2010
First published
07 Dec 2010

Org. Biomol. Chem., 2011,9, 994-997

Asymmetric organocatalytic Michael–α-amination sequence for the construction of a quaternary stereocenter

A. Desmarchelier, J. Marrot, X. Moreau and C. Greck, Org. Biomol. Chem., 2011, 9, 994 DOI: 10.1039/C0OB00751J

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