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Issue 6, 2011
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TBAF-Catalysed silver oxide-mediated cross-coupling of functional trimethysilylpyridines: access to arylpyridines and bihetaryl compounds

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Abstract

The concomitant use of silver oxide and catalytic amount of TBAF allowed the efficient and chemoselective coupling of readily available 4-chloro- and 4-methyl-2-trimethyl-silyl-pyridines with heteroaromatic and aromatic halides. Based on control experiments, a mechanism involving the formation of a pyridylsilver intermediate and TBAF recycling is postulated.

Graphical abstract: TBAF-Catalysed silver oxide-mediated cross-coupling of functional trimethysilylpyridines: access to arylpyridines and bihetaryl compounds

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Publication details

The article was received on 13 Sep 2010, accepted on 09 Dec 2010 and first published on 24 Jan 2011


Article type: Paper
DOI: 10.1039/C0OB00710B
Citation: Org. Biomol. Chem., 2011,9, 1768-1773
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    TBAF-Catalysed silver oxide-mediated cross-coupling of functional trimethysilylpyridines: access to arylpyridines and bihetaryl compounds

    F. Louërat, H. Tye, S. Napier, M. Garrigou, M. Whittaker and P. C. Gros, Org. Biomol. Chem., 2011, 9, 1768
    DOI: 10.1039/C0OB00710B

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