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Issue 3, 2011
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Synthesis of difluoroaryldioxoles using BrF3

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A novel synthesis of different aromatic and heteroaromatic difluorodioxole derivatives has been developed. The starting materials were catechols, which, after treatment with thiophosgene, formed at 0 °C the respective thiodioxoles. The latter were reacted for a short time with commercially available bromine trifluoride, producing potentially biologically important difluoroaryldioxoles in moderate to high yields.

Graphical abstract: Synthesis of difluoroaryldioxoles using BrF3

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Publication details

The article was received on 12 Aug 2010, accepted on 02 Nov 2010 and first published on 03 Dec 2010

Article type: Paper
DOI: 10.1039/C0OB00571A
Citation: Org. Biomol. Chem., 2011,9, 902-905
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    Synthesis of difluoroaryldioxoles using BrF3

    Y. Hagooly, M. J. Welch and S. Rozen, Org. Biomol. Chem., 2011, 9, 902
    DOI: 10.1039/C0OB00571A

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