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Issue 2, 2011
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Synthesis of substituted 8-aminoquinolines and phenanthrolines through a Povarov approach

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Abstract

The synthesis of 8-aminoquinolines and 1,10-phenanthrolines with substituents in α of the nitrogen has been performed through an inverse-demanding aza-Diels–Alder (Povarov reaction) in the fluoroalcohols TFE or HFIP. This path involves simple starting materials: 1,2-phenylenediamines, enol ethers and aldehydes.

Graphical abstract: Synthesis of substituted 8-aminoquinolines and phenanthrolines through a Povarov approach

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Publication details

The article was received on 27 Jul 2010, accepted on 23 Sep 2010 and first published on 18 Oct 2010


Article type: Communication
DOI: 10.1039/C0OB00496K
Citation: Org. Biomol. Chem., 2011,9, 347-350
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    Synthesis of substituted 8-aminoquinolines and phenanthrolines through a Povarov approach

    K. De, J. Legros, B. Crousse, S. Chandrasekaran and D. Bonnet-Delpon, Org. Biomol. Chem., 2011, 9, 347
    DOI: 10.1039/C0OB00496K

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