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Issue 1, 2011
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Oxidative amide synthesis directly from alcohols with amines

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Abstract

Transition metal catalyzed oxidative amide synthesis directly from primary alcohols and amines is a highly atom economical transformation that evolves hydrogen gas as the only by-product. Several Ru-, Rh-based homogeneous and Ag-based heterogeneous catalysts have been developed for direct amide synthesis. Most of the developed catalysts showed excellent activity with sterically unhindered alcohols and amines; however, limited activity was observed with sterically hindered alcohols or amines, less basic aryl amines, and secondary amines. This account provides an overview of recent advances and challenges in direct amide synthesis.

Graphical abstract: Oxidative amide synthesis directly from alcohols with amines

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Publication details

The article was received on 29 Jun 2010, accepted on 21 Sep 2010 and first published on 09 Nov 2010


Article type: Emerging Area
DOI: 10.1039/C0OB00342E
Citation: Org. Biomol. Chem., 2011,9, 20-26
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    Oxidative amide synthesis directly from alcohols with amines

    C. Chen and S. H. Hong, Org. Biomol. Chem., 2011, 9, 20
    DOI: 10.1039/C0OB00342E

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