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Issue 1, 2011
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First total synthesis of (−)- and (+)-6-O-desmethylantofine

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Abstract

The first total synthesis of (−)-6-O-desmethylantofine (A) and its unnatural enantiomer (+)-6-O-desmethylantofine (B) is described. The synthetic route is efficient and practical with easily available glutamic acid dimethyl ester hydrochloride as the chiral material under mild conditions.

Graphical abstract: First total synthesis of (−)- and (+)-6-O-desmethylantofine

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Publication details

The article was received on 18 Jun 2010, accepted on 12 Aug 2010 and first published on 04 Nov 2010


Article type: Paper
DOI: 10.1039/C0OB00287A
Citation: Org. Biomol. Chem., 2011,9, 141-145
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    First total synthesis of (−)- and (+)-6-O-desmethylantofine

    M. Wu, L. Li, B. Su, Z. Liu and Q. Wang, Org. Biomol. Chem., 2011, 9, 141
    DOI: 10.1039/C0OB00287A

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