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Issue 10, 2011
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Synthesis of well-dispersed layered double hydroxide core@ordered mesoporous silica shell nanostructure (LDH@mSiO2) and its application in drug delivery

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Abstract

We demonstrate an efficient synthesis of novel layered double hydroxide mesoporous silica core–shell nanostructures (LDH@mSiO2) that have a hexagonal MgAl-LDH nanoplate core and an ordered mesoporous silica shell with perpendicularly oriented channels via a surfactant-templating method. Transmission electron microscopy, X-ray diffraction and N2 sorption analyses confirmed that the obtained nanostructures have uniform accessible mesopores (∼2.2 nm), high surface area (∼430 m2 g−1), and large pore volume (∼0.22 cm3 g−1). Investigations of drug release and bio-imaging showed that this material has a slow release effect of ibuprofen and good biocompatibility. This work provides an economical approach to fabricate LDH@mSiO2 core–shell nanostructures, which may have great potential in broad drug delivery and hyperthermia therapy applications.

Graphical abstract: Synthesis of well-dispersed layered double hydroxide core@ordered mesoporous silica shell nanostructure (LDH@mSiO2) and its application in drug delivery

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Publication details

The article was received on 04 Jul 2011, accepted on 20 Jul 2011 and first published on 22 Aug 2011


Article type: Communication
DOI: 10.1039/C1NR10718F
Citation: Nanoscale, 2011,3, 4069-4073
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    Synthesis of well-dispersed layered double hydroxide core@ordered mesoporous silica shell nanostructure (LDH@mSiO2) and its application in drug delivery

    H. Bao, J. Yang, Y. Huang, Z. P. Xu, N. Hao, Z. Wu, G. Q. (. Lu and D. Zhao, Nanoscale, 2011, 3, 4069
    DOI: 10.1039/C1NR10718F

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