Issue 5, 2011
From the journal:

Nanoscale

Encapsulated enhanced green fluorescence protein in silicananoparticle for cellular imaging†

Zhengwei Cai,a   Zhangmei Ye,a   Xiaowei Yang,a   Yanli Chang,a   Haifang Wang,*a   Yuanfang Liuab  and  Aoneng Cao*a  

* Corresponding authors

a Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai, China
E-mail: ancao@shu.edu.cn, hwang@shu.edu.cn
Fax: +86-21-66135275
Tel: +86-21-66135277-102

b Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, China

Abstract

The enhanced green fluorescence protein (EGFP) is efficiently encapsulated in silica nanoparticle by multiple covalent bonds. The silica encapsulation greatly increases EGFP's fluorescence intensity and stabilities against protease, denaturant and heat, making it a potential fluorescence probe for cellular imaging.

Graphical abstract: Encapsulated enhanced green fluorescence protein in silica nanoparticle for cellular imaging

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Article information

DOI
https://doi.org/10.1039/C0NR00956C
Article type
Communication
Submitted
07 Dec 2010
Accepted
28 Jan 2011
First published
03 Mar 2011

Nanoscale, 2011,3, 1974-1976

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Encapsulated enhanced green fluorescence protein in silica nanoparticle for cellular imaging

Z. Cai, Z. Ye, X. Yang, Y. Chang, H. Wang, Y. Liu and A. Cao, Nanoscale, 2011, 3, 1974 DOI: 10.1039/C0NR00956C

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