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Issue 9, 2011
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Design, synthesis, and structure–activity relationships of 1,3,4-oxadiazol-2(3H)-ones as novel FAAH inhibitors

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Abstract

Novel 5-aryloxy substituted 3-phenyl-1,3,4-oxadiazol-2(3H)-ones were prepared and identified as potent inhibitors of FAAH. In vitro SAR are discussed. Structural variations of the selected lead compound were explored in order to optimise in vivo efficacy and selectivity.

Graphical abstract: Design, synthesis, and structure–activity relationships of 1,3,4-oxadiazol-2(3H)-ones as novel FAAH inhibitors

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Publication details

The article was received on 18 Feb 2011, accepted on 03 Jul 2011 and first published on 03 Aug 2011


Article type: Concise Article
DOI: 10.1039/C1MD00136A
Citation: Med. Chem. Commun., 2011,2, 889-894
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    Design, synthesis, and structure–activity relationships of 1,3,4-oxadiazol-2(3H)-ones as novel FAAH inhibitors

    L. E. Kiss, H. S. Ferreira, A. Beliaev, L. Torrão, M. J. Bonifácio and D. A. Learmonth, Med. Chem. Commun., 2011, 2, 889
    DOI: 10.1039/C1MD00136A

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