Discovery and pharmacological characterization of a selective delta opiate receptor antagonist (CP-646,777)†
Abstract
CP-646,777 (compound 2a) is identified as a potent and selective delta
* Corresponding authors
a
Neuroscience Medicinal Chemistry, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT, USA
E-mail:
spiros.liras@pfizer.com
b Neuroscience Biology, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT, USA
c Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, CT, USA
CP-646,777 (compound 2a) is identified as a potent and selective delta
S. Liras, S. F. McHardy, M. P. Allen, B. E. Segelstein, S. D. Heck, D. K. Bryce, A. W. Schmidt, R. O'Connor, M. Vanase-Frawley, E. Callegari and S. McLean, Med. Chem. Commun., 2011, 2, 413 DOI: 10.1039/C0MD00249F
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