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Issue 4, 2011
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Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies

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Abstract

A novel series of diphenylbutylpiperidine derivatives in which a benzo-five or six membered heterocycle was linked at the 4-position of the piperidine moiety were designed and synthesized. Structure–activity relationship (SAR) studies of these compounds indicated that some molecules show promising autophagy inducing activity. Replacement of the fluorine atom by a CF3 group on the diphenyl part resulted in significant enhancement of the autophagy inducing effect. In the addition, a group of diphenylpentyl nitriles also showed similar bioactivities.

Graphical abstract: Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies

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Publication details

The article was received on 27 Nov 2010, accepted on 27 Jan 2011 and first published on 28 Feb 2011


Article type: Concise Article
DOI: 10.1039/C0MD00236D
Citation: Med. Chem. Commun., 2011,2, 315-320
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    Diphenylbutylpiperidine-based cell autophagy inducers: Design, synthesis and SAR studies

    G. Chen, H. Xia, Y. Cai, D. Ma, J. Yuan and C. Yuan, Med. Chem. Commun., 2011, 2, 315
    DOI: 10.1039/C0MD00236D

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